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C. H. Chen's Lab

Microfluidic Digital Medicine

S. Lian, S. Guo, K. Ren, Y. Xu, J. Ho, C. Chen, NANOSCALE 13, 20531–20540 (2021).

Heterogeneous multi-compartmental DNA hydrogel particles prepared via microfluidic assembly for lymphocyte-inspired precision medicine

 

Sophie Wan Mei Lian, Song Guo, Kewei Ren, Ying Xu, John S. Ho and Chia-Hung Chen* 
Nanoscale

 

Lymphocytes play a vital role in immunosurveillance through sensing biomolecules and eliminating targeted invaders. Compared with conventional therapies that depend on drug loading, lymphocytes are advantageous as they are able to ensure self-regulated therapeutics. Here, novel multi-compartmental DNA hydrogel particles were synthesized using a microfluidic assembly for intelligent cancer treatment via the logic-based control of siRNA release without external stimulation. The sensing sequence (D1) was compartmentalized from the treatment sequence (D2) with the use of core-shell DNA hydrogel particles. When D1 detects a cancer-associated biomarker, miRNA-21, a sequence cascade is triggered to release siRNA from D2, effectively eliminating the targeted cancer cells via lymphocyte-inspired precision medicine.

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Home  ꄲ  Research  ꄲ  CMC  ꄲ  S. Lian, S. Guo, K. Ren, Y. Xu, J. Ho, C. Chen, NANOSCALE 13, 20531–20540 (2021).
Created on:2021-12-16 12:00
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